They recently wrapped filming scenes in Venice, after production was marred by delays amid the coronavirus crisis.
And Tom Cruise and Hayley Atwell were seen shooting intense scenes at Fori Imperiali, in Rome, on Saturday.
The Hollywood legend, 58, and Agent Carter star, 38, wore concerned expressions as they filmed while handcuffed together and sat outside a police car.
Back to work: Tom Cruise and co-star Hayley Atwell were handcuffed together as they filmed intense scenes for Mission Impossible 7 in Rome on Saturday
Tom transformed into his character Ethan Hawke by wearing a grey waistcoat and matching suit trousers for a dapper display.
The actor completed the look by teaming a white button-up shirt with a grey tie, while he also wore black lace-up boots.
Hayley, meanwhile, wore a white open-collared shirt that she tucked into a pair of chic black pinstripe trousers.
Her brunette locks were brushed into a sleek, straight style, and she wore a light palette of make-up for the scene.
Drama: The Hollywood legend, 58, and Agent Carter star, 38, wore concerned expressions as they filmed the new scenes
Off camera: Tom and Hayley were seen chatting away in between takes
Stylish: Hayley, meanwhile, wore a white open-collared shirt that she tucked into a pair of chic black pinstripe trousers
The shoot is understood to be nearing completion after a turbulent filming schedule caused by the ongoing coronavirus health crisis.
In October Tom held crisis talks with director Christopher McQuarrie after 12 people on set reportedly tested positive for COVID-19.
Health chiefs were said to be tracing the contacts of those who tested positive after filming was suspended, dashing hopes it was an isolated case.
It appeared to be yet another blow for the action movie franchise after filming was suspended earlier this year during the first European wave of coronavirus when cases rose sharply in Italy.
Stylish: Hayley’s brunette locks were brushed into a sleek, straight style, and she wore a light palette of make-up for the scene
Preparations: Tom and Hayley were seen going through the shoot together before cameras began rolling
Ready to go: Tom was seen arriving on set with his mask on and a black coat which he took off so that he could get to work
The actor and the director, who worked together on previous Mission Impossible movies and Jack Reacher, were deep in conversation at their luxury base in the city, days after the situation came to light, but filming has now been allowed to continue with production restarting in recent weeks.
In October, The Sun reported 150 extras for the film were informed they were not to come in to shoot scenes that were on the filming schedule for the evening.
While no official reason was given for the sudden decision, it was claimed a coronavirus test had come back positive from the production so filming needed to be suspended temporarily.
A source speaking to the publication claimed: ‘There are about 150 extras involved in the filming and late on Thursday they were all told not to turn up for work and they would be notified when they would be allowed back on set.
Almost there: The shoot is understood to be nearing completion after a turbulent filming schedule caused by the ongoing coronavirus health crisis
Delays: In October Tom held crisis talks with director Christopher McQuarrie after 12 people on set reportedly tested positive for COVID-19
‘No official reason has been given but it’s feared it’s down to COVID and this will be the second time the production has been hit because of the virus.’
Crew also urged members of the public to remain socially distanced from one another as they waited to see the stars, while Tom and director Christopher are also said to have made the request.
MailOnline contacted Paramount Pictures and Tom Cruise’s representatives for comment at the time.
Outbreak: Health chiefs were said to be tracing the contacts of those who tested positive after filming was suspended, but production was allowed to resume earlier this month
Delays: In October, it was reported 150 extras were informed they were not to come in to shoot scenes that were on the filming schedule (Tom and co-star Hayley pictured in October)
Earlier this year, filming for the upcoming action movie was halted in Italy after cases of coronavirus rose sharply.
The crew and actors headed to Norway to film instead, before returning to the Italian capital to continue with scenes once it was safe to do so.
It was reported this summer that Hollywood legend Tom hired a £500,000 ship for the film’s crew in Norway to avoid any coronavirus-related delays.
The filming had already been delayed for months after COVID-19 spread across Italy, where production had been based in March, leading the release date to be pushed back to November 2021.
Frustrating: Filming was already delayed for months after COVID-19 spread across Italy, where production had been based in March, leading the release to be pushed back
‘They are terrified of further delays. Tom is determined not to see any more hold-ups. The studio believes it will keep everyone safe and get this shoot wrapped up’, a source told The Sun earlier this summer.
It was recently claimed that Tom was ‘exempt from Norway’s quarantine rules’ as he restarted filming in the Scandinavian country.
The media personality revealed how ‘excited’ he was to start shooting the latest instalment of the franchise in a phone call with Norway’s Minister of Culture Abid Raja.
Mission Impossible 7 will be released on November 19, 2021.
Delays: The film is scheduled for released on November 19 2021